Catalogue number: A726150
Chemical name: Apatinib
Synonyms: N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide; YN968D1 ;
CAS Number: 811803-05-1
Possible CAS #: NA
Molecular form.: C₂₄H₂₃N₅O
Appearance: Yellow Solid
Melting Point: 111-114°C
Mol. Weight: 397.47
Storage: Refrigerator
Solubility: Chloroform, DMSO, Methanol
Stability: No Data Available
Category: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors,
Boiling Point: No Data Available
Applications: Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
Dangerous Goods Info: NA
References: Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);
Peer Review Product Citations:

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  Pack size Price(USD)
10mg $150.00
100mg $1195.00
  Pack size Price(USD)
50mg $700.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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