6-Amino-4-(4-phenoxyphenylethylamino)quinazoline

Catalogue number: A621350
Chemical name: 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
Synonyms: N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine; QNZ;
CAS Number: 545380-34-5
Possible CAS #: NA
Molecular form.: C₂₂H₂₀N₄O
Appearance: Off-White to Brownish-Yellow Solid
Melting Point: >170°C (dec.)
Mol. Weight: 356.42
Storage: Refrigerator, Under Inert Atmosphere
Solubility: DMSO, Methanol (Sparingly)
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Inhibitors
Boiling Point: No Data Available
Applications: QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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