4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methyl-d3-picolinamide Hydrochloride

Catalogue number: A609747
Chemical name: 4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methyl-d3-picolinamide Hydrochloride
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₁₉H₁₅D₃ClFN₄O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 407.84
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Impurities, Isotope Labelled Compounds
Boiling Point: No Data Available
Applications: 4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methyl-d3-picolinamide Hydrochloride is the labeled analogue of 4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methylpicolinamide Hydrochloride (A609745), an impurity of Regorafenib (R143000), which inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Dangerous Goods Info: NA
References: Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)
Peer Review Product Citations:

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