17-(Allylamino) Geldanamycin

Catalogue number: A549650
Chemical name: 17-(Allylamino) Geldanamycin
Synonyms: 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)-17-desmethylgeldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; 17AAG; CP 127374; KOS 953; NSC 330507; Tanespimycin; 17-AAG
CAS Number: 75747-14-7
Possible CAS #: NA
Molecular form.: C₃₁H₄₃N₃O₈
Appearance: Dark Purple Solid
Melting Point: >194°C (dec.)
Mol. Weight: 585.69
Storage: -20°C Freezer, Under Inert Atmosphere
Solubility: Chloroform, DMSO, Methanol
Stability: No Data Available
Category: Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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