Catalogue number: A470700
Chemical name: Alamethicin
Synonyms: (3S,12R)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((R)-1-(2-Acetamido-2-​methylpropanoyl)pyrrolidin-2-yl)-15-(3-amino-3-oxopropyl)-30-isobutyl-21-isopropyl-​3,3,6,9,9,2,18,18,24,24,33,33-dodecamethyl-1,4,7,10,13,16,19,22,25,28,31-​undecaoxo-2,5,8,11,14,17,20,23,26,29,32-undecaazatetratriacontan-34-​oyl)pyrrolidin-2-yl)-12-(((R)-5-amino-1-(((S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1,​5-dioxopentan-2-yl)carbamoyl)-3-isopropyl-6,6,9,9-tetramethyl-1,4,7,10-tetraoxo-2,5,​8,11-tetraazapentadecan-15-oic Acid;
CAS Number: 27061-78-5
Possible CAS #: NA
Molecular form.: C₉₂H₁₅₀N₂₂O₂₅
Appearance: Light Beige to Brown Solid
Melting Point: >175°C (dec.)
Mol. Weight: 1964.31
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Aromatics, Peptides, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride. Alamethicin contains the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib), which strongly induces helical peptide structures. In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules.
Dangerous Goods Info: NA
References: Afonin, S., et al.: Chembiochem., 4, 1151 (2003), Henriques, S., et al.: Biochem. J., 399, 1 (2006), Almeida, P., et al.: Biochemistry, 48, 8083 (2009), Heitz, F., et al.: Br. J. Pharmacol., 157, 195 (2009),
Peer Review Product Citations:

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  Pack size Price(USD)
1mg $65.00
10mg $475.00
50mg $1725.00
  Pack size Price(USD)
5mg $260.00
25mg $950.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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