AG-490

Catalogue number: A425000
Chemical name: AG-490
Synonyms: 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; Tyrphostin B 42;
CAS Number: 134036-52-5
Possible CAS #: NA
Molecular form.: C₁₇H₁₄N₂O₃
Appearance: Dark Yellow Solid
Melting Point: >213°C (dec.)
Mol. Weight: 294.3
Storage: -20°C Freezer
Solubility: Acetone, Chloroform, DMSO, Ethanol, Methanol
Stability: No Data Available
Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors,
Boiling Point: No Data Available
Applications: A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Dangerous Goods Info: Not a dangerous good if item is equal too or less than 1g/ml and there is less than 100g in the package
References:
Peer Review Product Citations:

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  Pack size Price(USD)
5mg $50.00
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25mg $125.00
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100mg $450.00
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  Pack size Price(USD)
10mg $75.00
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50mg $240.00
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250mg $875.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   In Stock

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