Adamantan-2-ol-6-one was used in the preparation and SAR studies of polycyclic acids as potent and selective inhibitors of human 11β-Hydroxysteroid dehydrogenase type 1, the enzyme that catalyze the conversion of Cortisone (C696500) to active cortisol.
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Ye, X.Y., et al.: Bioorg. Med. Chem. Lett., 21, 6699 (2011);