ABT 888

Catalogue number: A112580
Chemical name: ABT 888
Synonyms: 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide; A 861695;
CAS Number: 912444-00-9
Possible CAS #: NA
Molecular form.: C₁₃H₁₆N₄O
Appearance: Off-White to Pale Beige Solid
Melting Point: >173°C (dec.)
Mol. Weight: 244.29
Storage: Refrigerator
Solubility: Methanol (Slightly), THF (Slightly, Heated)
Stability: No Data Available
Category: Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
Dangerous Goods Info: NA
References: Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002), Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2003), Kim, M., et al.: Cell, 119, 803 (2004), Tentori, L., et al.: Pharmacol. Res., 52, 25 (2005),
Peer Review Product Citations:

Order Product

  Pack size Price(USD)
5mg $65.00
25mg $225.00
100mg $570.00
  Pack size Price(USD)
10mg $110.00
50mg $345.00
200mg $895.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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