trans-Abacavir Dihydrochloride

Catalogue number: A104995
Chemical name: trans-Abacavir Dihydrochloride
Synonyms: (1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Diydrochloride;
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₁₄H₂₀Cl₂N₆O
Appearance: Pale Yellow to Pale Orange Solid
Melting Point: >144°C (dec.)
Mol. Weight: 359.25
Storage: Refrigerator
Solubility: DMSO, Water (Slightly)
Stability: No Data Available
Category: Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info: NA
References: PMID: 22267465
PMID: 18479171
Peer Review Product Citations:

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